The McGuire Nuclear Station is a nuclear power plant located about 17 miles northwest of Charlotte, North Carolina, on the state's largest lake, Lake Norman. It is a 32,500-acre lake created in 1963 by Duke Power for the Cowans Ford Hydroelectric Station. The McGuire units use the lake's water for cooling.

This plant has two Westinghouse pressurized water reactors and has a capability to produce 2,250 megawatts of net power, with a net generation of 17,514 GW·h in 2005. This represents 44% of the total nuclear power generation for the state of North Carolina.